H(Thu Oct 08 12:47:32 1998) From ultradia.vmfe,noqq$qq%O7L6('&)$%CD/+*,m}HIGFHd``    ? P$  $< )-9$ $$*<(-#I" 3.Z) ;+ D6 $M6 S8 X:$^2$b0 fS h^ ji lt n p  r" t$ v& x( z* |, ~. 4 D C$E $A$(N#$KR%$V'$G!  M;$7f. ZT&$^  w|(D3 V@u1 I5 X($1\*  4`+ b,$8$!d-$(<q/$0ay2$9)j(>K<s0 F6$M7$T4$\:$b4 @e\ u l(4 l(0l$0# l(0|l\ | ,<l\L,<Ll|| l|L<,<,\ <L\,l\LC7LuuSUMPRODVMINVMAXTimeINITIAL TIMEFINAL TIMETIME STEP SAVEPER.UltradiaBlood Glucose Level GlucoseGlucose Space Voll to dl Conversion Factor"Exogenous Glucose Delivery Rate"Exogenous Glucose Infusion RateG Infusion MagnitudeG Infusion OnOffG Infusion ProfileFood ProfileFood OnOffF1K1F1K2F1K3F2K1F2K2F3K1F4K1F4K2F4K3F4K4F5K1F5K2F5K3Food Profile LOOKUPSTEPGlucose Gain RateGlucose Loss RateGlucose Factor for IDGU RateHepatic Glucose Production&Insulin Dependent Glucose Use Rate&Insulin Independent Glucose Use Rate&Glucose Production Change Delay TimeEXPThird Ord Smooth of Plas InsPlasma Compartment VolInsulin Factor for IDGU RateLNRemote Insulin"Remote Insulin Compartment VolPlasma Remote Exchange RateRemote Insulin Decay TimeInsulin Secretionl to ml Conversion FactormU to U Conversion FactorPlas Insulin Gain Rate"Remote to Plasma Migration RatePlas Insulin Loss RatePlasma Insulin Decay Rate"Plasma to Remote Migration RatePlasma InsulinPlasma Insulin Decay TimeRemote Insulin Gain RateRemote Insulin Loss RateRemote Insulin Decay RateSerum Insulin Level SMooTH3 -Minute SMOOTH3INSTLV2DLLV1>#SMooTH3(PlasmaInsulin,GlucoseProductionChangeDelayTime)#B#LV2#DL9 Times New Roman!dIndicators & Inputs 5OmH7L64 ^ZU Ultradian Oscillation Modelvr ^0 Replicated by Hank Taylor, MIT; Translated to Vensim by Tom Fiddaman, 1998 tom@vensim.comfc ^ See: Jeppe Sturis, Kenneth S. Polonsky, Erik Mosekilde, and Eve van Cautervq ^  "Computer model for mechanisms underlying ultradian oscillations of insulin and glucose"ZU h Am. J. Physiol. 260 (Endocrinol. Metab. 23): E801-E809, 1991 #*06=DKRY_flsy H7L# ( 0 6 d 0Ld 0" D  " D  l%e4  8 h   |y  r      *( $    0=  +  GR  % h  S p L2` !*`*( ,( #W <2Pg %sn v2P 'DZ![ #*06=DKRY_flsyH7L ,l( 0e  d 0Jd 0" O  " O  dh   ,@T   dh  \xU a PP  w7*( (  : L`  #97  <g E8 #*06=DKRY_flsy")/6<BMS^dkqx~H7Loo p( 0  d 0b)d 0" |;  |" l;  rq  % Pu v 6`  V [   ,^ TNp h= xd*(   *(   *( 0  *( N   L` !|*( ,v( ## <g %r \NU 'M  )-  +-s*( nF  .@U`*( (p  0 ~ ,W 2  (J 42R? ,(^ 62[I <(r 82^R (P :2^] \ <2s  { ><@*( ( @<tn $*17>DKQXcitzH7L aog  l(   \( ( ,&C  <7  L7   a5i *( LnT   *( l(    <cv=  |O  [ ( P *( (  gB ,( b( > X= $< 6N JSH7L@:lG?|R'%* XCr%,#%<L%\l* |QC*%C**33@*/B*4C*9! #<*>%B*C)*H-Q@*M1 @*R54C*W9,z>*\=<@*aAl:fF\HLlrmJLu=? #=@)\=@@)\=@Q8=@Q8=@Ga=@=A{=A\= A= =0A= =@A)\=PA ף=`AQ=pAz>A>A=AG=AG=A=A333>AG>A(>A= =A)\=A)\=AQ8=A)\=A=A\=AG=B(>Bq= >B> BR>BR>*Y,bC* ]<zbL$\0?%\0??JfG$l||RFJ'j'%:/nl#:5r|#*;vB*@{ AE'#?$'%,<:T% [ #'#?#%%,#'?<'?%L\ t%$?%'l'|#?#'%* A*|zD*zD:#l:#*@@JG$B:'*@*LL>T'%LJ,G$ ffoC*<0A:,',\*\B* :#,J'%L,<b<'%%|JlL0*|*C*?*'*0Lb7G'$ bDG'$ bQG'$ :^'@@  Lh?XAkmo[tNqdsw[jlG'$|lj|G'$|B'@@rG'$\H7Lg&'% &XC.&,%<%L#\%l|&QC&C&33@&B&C& #<&B&$?&Q@ &@&4C,&z><&@l&\&LlbLu=? #=@)\=@@)\=@Q8=@Q8=@Ga=@=A{=A\= A= =0A= =@A)\=PA ף=`AQ=pAz>A>A=AG=AG=A=A333>AG>A(>A= =A)\=A)\=AQ8=A)\=A=A\=AG=B(>Bq= >B> BR>BR>,&bC<&6L&\?$%\??"&Gl$||RF&%'l&#|&#&B& A:&'?#,%'$<&% b &'?#%,%?'<#?'L%\## 2&%?$$'%:l&|'?#$'%#& A|&zD&zD&l#&#&@@"&G$B&'&@L&L>&L%'",&G $ffoC<&0A,&,'\\&B &&,#&L%,'<&<&%'%|&L|& \&C \&? \& \&&G$' &&G$' &&G$' &'@@ @H7LO&Internally defined simulation time.{mg/min, I}{1=On, 0=Off}{1=On, 0=Off}{min, t3}*{Glucose Space Volume, V3, in Liters} {dl/l} {ml/l} {U/mU}{V1, in Liters}{min, t1}{l/min, E}{V2, in Liters}{min, t2}{h3}XCQCC33@BC #<BQ@@4Cz>@CbCB A AzDzD@@@L>0AB?*%7LTT?@@@@@@@AA A0A@APA`ApAAAAAAAAAAAAAAAAABBB BBu= #=)\=)\=Q8=Q8=Ga=={=\== == =)\= ף=Q=z>>=G=G==333>G>(>= =)\=)\=Q8=)\==\=G=(>q= >>R>R>///---\\\ :L<%^E!@ 1:Current.vdf 9:Current 22:$,Dollar,Dollars,$s 22:Day,Days 22:Hour,Hours 22:Minute,Minutes,Min,Mins 22:Month,Months 22:Person,People,Persons 22:Unit,Units 22:Week,Weeks 22:Year,Years 15:0,0,0,0 19:100,0 4:Time 5:Food Profile LOOKUP